New generation technologies are generated through the pioneering integration of different paradigms, expertise and skillsets. For example, in the field of cutting-edge engineering, experts design, prototype, tinker, quantify and look for the weak spots where solutions can be made. In the area of immunology, scientists investigate, question, think and discover. Combining different fields as a ‘Whole-of-Science’ approach is imperative for innovations which detect and treat a broad range of diseases. New applications can meet the dynamics of a VUCA world of health and healthcare, alongside advancements in digital capabilities.